Citrus Aurantium Extract

Product Name: Citrus Aurantium Extract
Appearance: Dark brown powder
Mesh Analysis: Pass 80 mesh
Anthocyanidin ¡10%, 30%
Test Method: HPLC
Packing: 25Kg/drum
Application: dietary supplement, pharmaceutical, food and baverage, flavor and cosmetic industries.Latin name: Citrus aurantium
Chinese Pin-Yin name: Zhi Shi
Common name: Bitter Orange, green orange, sour orange
Family: Rutaceae
Genus: Citrus
Part Used: fruit (immature) History:
Citrus aurantium L, belonging to the family Rutaceae, is widely distributed in China. Zhishi, the Chinese traditional name for Citrus aurantium, has long been a folk medicine in traditional Chinese medicine (TCM)to improve indigestion and help stimulate the Qi (energy force). It also has been a folk remedy in Italy since the 16th century for fevers like malaria and as an antiseptic. Recent studies have confirmed that Zhishi, replacing Ma Huang, can be used for treatment of obesity without the negative cardiovascular side effects.Function:
Synepherine is the main active compound found in the fruit of Citrus aurantium, which is effective in providing the energy boost (caloric expenditure), aiding the expulsion of wind, warming the stomach, improving the appetite, and increasing metabolic rate. Citrus aurantium is theorized to stimulate fat metabolism without the negative cardiovascular side effects experienced by some people using Ma Huang. It is also a mild aromatic expectorant, a nervine and a laxation for constipation.1. Weight Loss
The most likely explanation for weight loss effects attributed to citrus aurantium supplements is the amphetamine-like effects of the alkaloids. Although this effect is likely to be somewhat less dramatic than effects induced by Ma Huang (ephedra alkaloids), users can expect variable effects including enhanced caloric expenditure, reduced appetite and heightened feelings of energy, all of which are likely to result in weight loss. [1], [2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12] A recent study conducted in dogs also suggests that synephrine can increase metabolic rate in a specific type of fat tissue known as Brown Adipose Tissue (BAT).
Since synephrine and several other compounds found in zhi shi are structurally similar to ephedrine and act as stimulants to specific adrenergic receptors (beta-3, but not beta-1, beta-2 or alpha-1), zhi shi does not appear to have the same negative central nervous effects of Ma Huang (ephedra), which stimulates all beta-adrenergic receptors.2. Mild Exhilarant
Studies have attributed the energy enhancing effect of synephrine to stimulation of the Centre Nervous System [12], [14]. This integrated effect may include increased circulation of blood through the heart and cerebral tissue [5], elevated blood pressure and improved mental activity, which would readily qualify synephrine as a mild exhilarant.3, Digestive Tract Discomfort
Conformed with traditional use, Citrus Seed Extract can stimulate the digestive tract by stimulating stomach functions as well as having laxative and gas-relieving actions [8, 13] It may also help relieve nausea and sooth stomach disturbances such as gas and bloating [4]4, Anti-Microbial Activities
Citrus Seed Extract is a non-toxic and organic anti-microbial product. It shows a bacteria growth inhibitory effect in vitro [11] and can also inhibit the infection capability of some viruses. [9] Thus the extract is wildly used as a sanitizing disinfecting agent, as a preservative in foods or cosmetics, and in agriculture as a fungicide, anti-bacterial, anti-parasitic and anti-viral agent.Dosage
Standardized synephrine as Citrus Aurantium fruit extract is recommended. A dose of 4-20 mg of synephrine per day is a typical dose found in products providing 200-600 mg of a standardized citrus aurantium extract (3-6% synephrine). [3]Safety
Both isolated synephrine and citrus aurantium extract have been shown to raise blood pressure in animal studies. Until more studies are conducted on the safety, pharmacology and efficacy of citrus aurantium as a thermogenic supplement, it should be treated as an ingredient with mild stimulant properties and should be avoided by individuals with cardiovascular concerns such as high blood pressure or heart problems [3, 4, 5, 8] No toxicity is reported by oral ingestion. Handled at full strength, avoid contact with eyes or breathing the vapor